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Various strategies can potentially mitigate ferroptosis in AD, such as antioxidant therapy using compounds like vitamin E or Lip-1 to reduce neurodegeneration, iron chelation therapy to control iron levels and limit the generation of ROS, modulation of glutamate signaling pathways to address excitotoxicity, regulation of lipid metabolism to prevent LPO, and activation of GPX4 to safeguard cells against LPO and ferroptosis (Park et al., 2021)

This review includes findings from in vitro , in vivo experiments as well as insights from clinical applications, as illustrated in Figure 1

Within this, oral peptides are projected to be a key driver, as consumers demand easier-to-use and non-invasive options

Neuroreport 23(6):400404 Nakamura E, Uneyama H, Torii K (2013a) Gastrointestinal nutrient chemosensing and the gut-brain axis: significance of glutamate signaling for normal digestion