glutathione phase i Detoxification: and Phase II Detox Genes The Transulphuration Pathway - Lifecode

Peters 1,2 , Erica DePasquale 1 , Gousia Begum 1 , Krishna Roskin 1,2 , E

Some scholars have used the synoviocyte mitochondrial gene encoding NADH dehydrogenase 1 as an entry point in order to study the mutation level of synoviocyte mtDNA in rheumatoid arthritis, and have found that the number of mutations in RA synoviocyte mtDNA is approximately twice as high as that of the OA group, and that RA fibroblasts are expressed at a mutation load of 2.3 amino acid changes per thousand base pairs, whereas in tissues, there are 2.3 changes per 2.5 amino acid changes per thousand base pairs

doi: 10.1016/j.cgh.2012.03.011 55

In summary, glutathione acts as a critical determinant in regulating the inflammatory potential of infiltrating immune cells