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Combination of metformin and luteolin synergistically protects carbon tetrachloride-induced hepatotoxicity: mechanism involves antioxidant, anti-inflammatory, antiapoptotic, and Nrf2/HO-1signaling pathway

doi:10.1186/1472-6882-11-15 Lee HE, Yang G, Park YB, et al.Epigallocatechin-3-gallate prevents acute gout by suppressing NLRP3 inflammasomeactivation and mitochondrial DNA synthesis

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Developing validated, tiered testing strategies that intelligently combine in vitro, in vivo, and mesocosm data is essential for making this challenge more tractable