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These results show that RIPS-1 is mildly induced by mitochondrial stress markers and strongly induced by the hypoxia-inducible factor cascade and controlled by HIF-1

2.6.4 Comparison and interaction with cuproptosis As two novel metal-dependent regulated cell death pathways, ferroptosis (iron-driven lipid peroxidation) and cuproptosis (excess copper leading to aggregation of lipoylated TCA cycle proteins and proteotoxic stress) have distinct core mechanisms (77, 78)

In both species, the foundress produces an initial haploid male egg followed by a series of female eggs and all offspring grow rapidly during a protonymph and deutonymph stage on the same host

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