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Often referred to as the master antioxidant, glutathione is essential for fighting oxidative stress and preventing premature aging and chronic diseases

The most investigated mechanisms with known clinical significance are: a) activation of transmembrane proteins effluxing different chemical substances from the cells (P-glycoprotein is the most known efflux pump)

However, the intranasal route of drug delivery still has some unresolved issues, such as the need to overcome cilia and mucosal clearance in the vestibular region, as well as enzymatic degradation after the introduction of nanotherapeutic formulations into the nasal cavity[166]

It is characterized by unintentional weight loss predominantly from loss of skeletal muscle and adipose tissue [13]