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Environment, genetics, and metabolic dysfunctions may be the cause of the pathophysiological development of NAFLD, such as alterations in liver lipid constituents, cellular impairment, and tumorigenesis [219]

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A critical review of anticancer properties of Withania somnifera (L.) Dunal with respect to the biochemical mechanisms of its phytochemical constituents

Another major advantage to expressing proteins in the cytoplasm is the presence of the many energy-dependent chaperones that facilitate correct folding of proteins, which are absent in the periplasm (for example, GroEL/S, ClpXP and DnaKJ systems)