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Here we investigated cellular and molecular responses associated with these combined agents, and their potential to induce multi-drug resistance against the temozolomide (TMZ) and etoposide (EP) used in glioblastoma maintenance treatment

In detail, when combined with RT, shrinkage was observed in 9 out of 13 and only 1 out of 17 individual tumor nodules in the LDHB knockout versus wild-type background, respectively (Fig