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Zeichner about this skin purge theory though, he pretty much nixed it

doi: 10.3389/fmolb.2023.1127690 Received 19 December 2022 Accepted 23 January 2023 Published 02 February 2023 Volume 10 - 2023 Edited by Katherine Vest, College of Medicine, University of Cincinnati, United States Reviewed by Elena Polishchuk, Telethon Institute of Genetics and Medicine (TIGEM), Italy Ashutosh Kumar Pandey, The State University of New Jersey, United States Updates Copyright 2023 Philpott, Protchenko, Wang, Novoa-Aponte, Leon-Torres, Grounds and Tietgens

Vitamin Supplementation Initiate folic acid 400 mcg to 1,000 mcg orally once daily, beginning 7 days before the first dose of pemetrexed for injection and continuing until 21 days after the last dose of pemetrexed for injection [see Warnings and Precautions (5.1)]

Taub 2 , Ya-Yun Ren 3 , Elaine Lay Khim Chng 1 and Stephen A Harrison 4 , (1)Histoindex Pte Ltd, Singapore, (2)Madrigal Pharmaceuticals, (3)Histoindex Pte Ltd, (4)Pinnacle Clinical Research Center, San Antonio, TX Background: Resmetirom is an oral, liver-targeted thyroid hormone receptor- selective agonist that reduces biopsy component scores