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Interestingly, the two carcinogens S-NNN (IARC 2007) and NMA (Zielenska and Guttenplan 1988) induced DNA strand breaks in HepG2 cells with hamster S9-mix only but not in the other liver cell models (Table 4)

Unsupervised principal component analysis (PCA) and hierarchical clustering analysis (HCA) on normalized data from all cell samples were conducted using the ArrayTrack software system developed by the U.S