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The circulating amino acids then are reabsorbed into the cell and re-assembled to produce glutathione in the cell

Phase I metabolism, as a general rule, generates very reactive oxidising compounds

Lipid peroxides released early during ferroptosis act as damage-associated molecular patterns (DAMPs), promoting dendritic cell (DC) maturation and antigen cross-presentation, which in turn primes CD8 + T cells and enhances anti-tumor immunity ( + T cells and DCs, thereby positioning CDH4 as a promising target for combination therapies leveraging ferroptosis and immunotherapy