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That figure came from an assay-specific in-vitro spine-density assay (picomolar Dihexa versus nanomolar BDNF) and does not mean Dihexa is millions of times more effective in a living brain

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HGF/c-Met signaling pathway with its downstream effector components (MAPK, STAT, PI3K-AKT cascades and NF-B) increase cell survival, motility and proliferation [51]