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Indeed, microglia are crucial for the elimination of myelin debris by phagocytosis, a prerequisite for remyelination (Napoli and Neumann, 2010

However, they often show direct RS scavenging or other biological activity (e.g., inhibition of topoisomerase II)

When the drug cannot reach sufficient intracellular concentrations, the cells may survive through intrinsic drug resistance mechanisms and gradually evolve into drug-resistant tumors

VIC also stimulates iron absorption at the intestinal level by reducing Fe 3+ to Fe 2+ , making it more stable and contributing to anemia management [2,8,10]