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Ferroptosis induces tumor cell death through lipid peroxidation, accompanied by the release of immune-stimulatory signals (such as ATP and HMGB1), forming a synergistic effect with ICD

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Overall, tissue homeostasis is maintained within a bounded ROS window

Energy metabolism and cortical spreading depression susceptibility Cortical spreading depression (CSD) is a neurophysiological phenomenon characterized by the strong depolarization of regional neurons or glial cells, spreading along the cortex to neighboring regions at a rate of 35 mm/min, ultimately leading to inhibition of neural activity (9)