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doi: 10.1038/s41392-023-01605-2 93 KythreotouASiddiqueAMauriFABowerMPinatoDJ

The consequent loss of PV-INs reduced inhibitory inputs onto pyramidal neurons (PNs), disrupting cortical excitatory/inhibitory (E/I) balance and causing PN hyperexcitability and cortico-striatal pathway dysfunction