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It is a major source of morbidity and mortality worldwide, with an estimated 12 million new cases occurring annually, with an increasing incidence due to aging populations and associated risk factors such as hypertension, diabetes, and smoking (An et al

Since ROS exert positive and negative effects on cell proliferation and survival, intracellular ROS levels are regulated by multiple factors 25,29 , among which GSH appears to play a major role

Use of genetic variants to predict clinical outcome in patients (pts) with metastatic colorectal cancer (mCRC) treated with first-line 5-FU or capecitabine in combination with oxaliplatin and bevacizumab (FOLFOX/BV or XELOX/BV)