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It is a chronic condition that can significantly impair the patients quality of life, including their ability to work, maintain social relationships, and engage in sexual activity

Replacement of the L-amino acids of 23 with D-amino acids were not productive (Andersson et al., 2010)

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Recently, dipeptidyl peptidase 1 (DPP1) has emerged as a promising therapeutic target, functioning as the critical regulatory enzyme for NSP activation (Zhong et al., 2025)