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J Proteome Res 9 , 144163, doi: 10.1021/pr900831f (2009)

Eradication of neuroblastoma by T cells redirected with an optimized GD2-specific chimeric antigen receptor and interleukin-15

Oxymatrine, a naturally occurring antioxidant alkaloid is also known to exhibit a chemopreventive effect against human glioblastoma cells by inducing apoptosis, suppressing invasion, and arresting the cell cycle by suppressing PI3K/Akt/mTOR signaling and downregulating STAT3 and EGFR activation, thereby counteracting with metabolic remodeling in brain cancer cells [251, 257]