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Comparative Position Among GH Secretagogues Within the broader class of ghrelin-receptor-targeting compounds, ghrelin itself is understood as a multifunctional peptide, primarily synthesized in the stomach, that regulates GH secretion and energy homeostasis while playing a broader role in diverse physiological and pathological processes

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Other hormones, neuronal signals, and factors associated with circadian rhythms and physiological states may also modulate its potential appetite-stimulating effects