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4 Therapeutic innovations and paradigmatic advances in traditional Chinese medicine: evidence-based insights through the gut-kidney axis framework Contemporary evidence-based medical research has unequivocally established TCM as a therapeutic modality of unprecedented sophistication in CKD managementits integrative, precision-oriented, and holistic philosophical paradigm fundamentally transcends conventional therapeutic frameworks, effectuating profound amelioration of uremic toxin homeostasis and nephroprotective mechanisms (Li et al., 2019)