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Surprisingly, these anti-inflammatory benefits have recently been attributed to central neuronal GLP-1RAs [171], highlighting the potential use of incretin receptor agonists for neurological diseases with inflammatory components

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It also reduces the intramitochondrial ratio of acetyl-CoA to free CoA, which in turn stimulates pyruvate dehydrogenase activity and promotes pyruvate oxidation

This highlights the critical need for novel, well-tolerated, and with alternative mechanisms to broaden MDD treatment options, especially Acetyl-L-Carnitine (ALC)