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Both work through similar mechanisms (GABA enhancement, glutamate modulation) but at different receptor sites, creating complementary calming effects

Interestingly, at acidic pH, the protein uses NAD phosphate (NADP) as a substrate to produce nicotinamide adenine dinucleotide phosphate (NAADP), which is hydrolyzed to ADP-ribose 2'-phosphate (ADPRP) [2]