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These limitations are addressed in fed-batch and continuous exchange (also referred to as semicontinuous) setups in which additional template, substrates, and/or energy sources are provided during the reaction, 29 increasing reaction longevity and/or yield

Considering the short half-life of ROS, its participation as a signalling molecule is probably dependent on the site of its generation, which would support the hypothesis of a key role for membrane-associated NOX in signal transduction at the plasma membrane [46]