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[DOI] [PubMed] [Google Scholar] 47.Singh RM, Cummings E, Pantos C, Singh J

The immunomodulatory influence of probiotics is further attributed to their direct engagement with a range of immune cells, including IECs, DCs, lymphocytes, and monocytes/macrophages (216)

4.1.2 Impact of pyruvate kinase and lactate on macrophage phenotype Pyruvate kinase is a key enzyme in the glycolysis pathway: it catalyzes the dephosphorylation of phosphoenolpyruvate into pyruvate and is responsible for the production of ATP during glycolysis

In assessing the CGI-I, one subject scored a 4 (no change/improvement), four subjects scored a 3 (minimally improved), and one subject scored a 6 (much worse)