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Moreover, significant changes in microbial communities combined with different dietary compositions may drive different molecular inputs to neuroendocrine signaling pathways, and these altered inputs (e.g., short-chain fatty acid response) combined with changes in the gut-brain axis may drive different systemic responses at the level of hormones and gene expression (49)

Removing CXXC5 suppression allows the body natural Wnt signaling to function normally, which is a more fundamental correction than adding external growth factors