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Another recent research in 2021 has reported lower metabolite concentrations of TRP pathway metabolites in both urine ( n = 560) and serum ( n = 354) samples of AD patients [164]

They observed no difference in this parameter between the presynaptic boutons even under high-intensity stimulation of neurotransmitter release (600AP) [58]

DerSimonian R, Laird N

[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Cascino A., Cangiano C., Fiaccadori F., Ghinelli F., Merli M., Pelosi G., Riggio O., Rossi Fanelli F., Sacchini D., Stortoni M., et al