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Since its inception in the early 1940s, Waddingtons concept of epigenetics took on additional meanings until encompassing the current notion of stochastic or environment-induced modifications of histone proteins or DNA without changes in the DNA sequence itself that alter the accessibility of genes to transcription factors [9]

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The alternative techniques fall in the HHST category but also include the UP (Ultra High-Temperature Pasteurization) process

AD is associated with several comorbidities, both allergic and non-allergic, indicating its systemic nature, particularly bacterial and fungal infections, neuropsychiatric disorders, autoimmune diseases, metabolic diseases and haematologic malignancies (914)