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For mitochondrial functionality, the model included group (CON or CAR), time (relative to LPS injection), stimulus (unstimulated, ConA or LPS) and their interactions as fixed factors

Consistent with this, KEGG pathway analysis revealed downregulation of -oxidation in KO mice, accompanied by upregulation of glycolysis and mitochondrial oxidative phosphorylation, reflecting a systemic shift in fuel preference toward carbohydrates driven by carnitine depletion and impaired fatty acid oxidation

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