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To understand the strong association between DS and AD neuropathology, first it is necessary to consider the trisomy of Chr21, in which the overexpression of selected genes already has been identified to be involved in the development of AD neuropathology in the general population (457) (FIGURE 11)

Huang N, Winans T, Wyman B, Oaks Z, Faludi T, Choudhary G et al (2024) Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation