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As shown in Figure 2 , they may first activate vagus nerve terminals which are located in the gut and project on the NTS in the brainstem

The catalytic mechanism of GSTZs differs from other GSTs in that GSH is initially conjugated to the cis double bond of maleylacetoacetate allowing the isomerisation reaction, before being eliminated in a second step allowing the formation of fumarylacetoacetate (Thom et al., 2001)