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In order to efficiently screen inhibitors, a direct system was established for virtual screening, protein expression, and inhibitor identification for SHMT2, which was used to virtually screen 210 thousand compounds from the Specs database for further screening by in vitro non-competitive kinetic assays catalyzed by SHMT2 monoenzyme [162]

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A 2015 British study found that medical practices in areas with fluoridated water were twice as likely to have patients with hypothyroidism