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Similar findings were reported in prospective clinical studies.68,69 A large multicenter RCT (n=194), however, found no significant differences with placebo.70 A meta-analysis of the above findings for a total of 480 patients showed a favorable effect on facial appearance.70 Multiple oral antioxidants and anti-inflammatory agents, such as vitamins A, C, D, and E, green tea polyphenols, niacinamide, and trace elements such as zinc may help mitigate signs of skin aging

Marek & Ramos, 2018

Genome editing in mitochondria corrects a pathogenic mtdna mutation in vivo

This raises intriguing questions as to the protective role of the ISR in other contexts of iron overload