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NRF2 target genes also involve PPP products such as G6PD, 6PGD, transketolase, and transaldolase, indicating that NRF2 activation is crucial for participating in and/or maintaining the PPP, especially for producing NADPH to fuel FAS, TRX, and GSH systems 172

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10.1016/j.plipres.2018.09.002 83 LeiP.BaiT.SunY

Available safety data suggest that S-acetyl glutathione has a favorable safety profile when consumed appropriately.