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Zhu, X.-N

This identified several potential components of the Retromer sub-domain including the endosome-to-TGN SNARE VAMP3, sorting nexin-29 (SNX29), the caveolae associated caveolin-1 (CAV1) and CAVIN1, subunits of the octameric augmin complex (HAUS2, HAUS5, HAUS6, HAUS8), which interacts with the -tubulin ring complex (TuRC) to stabilise pre-existing microtubules and facilitate microtubule branching during chromosomal segregation and neuronal migration, development, and polarisation 70,71,72,73,74,75 , and the late endosomal 2Cl /H + exchanger CLCN7 dysfunction in this exchanger leads to a lysosomal storage disease and neurodegeneration in humans 76

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IFX is a chimeric human-mouse immunoglobulin (Ig) G1 mAb that binds to and neutralizes TNF-