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Various factors may have contributed to these mixed results, including participant heterogeneity, compliance issues, and the aggressive placebo response often seen in obesity trials where lifestyle modification is encouraged

Medication Management (FirstLine) Medications are often the first treatment option and may include: Anticonvulsants (e.g., carbamazepine, oxcarbazepine) Muscle relaxants Other nerve pain medications These medications help calm abnormal nerve signaling and reduce the frequency and intensity of pain episodes