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For the beta diversity analyses, an analysis of similarities (ANOSIM) was performed on each of the distance/dissimilarity matrices to establish whether observed clustering by treatment group was statistically significant

B12 is delivered through an IV infusion by inserting a small catheter into a vein, allowing a saline-based solution containing vitamin B12 to flow directly into the bloodstream

When NNMT activity is inhibited, these methyl donors become available for other methylation reactions in the body

This work was funded by: TS (Baylor College of Medicine, U01-AI24290, P01-AI152999, NINR R01-NR013497, and NIDDK P30-DK56338), SJW (NIDDK 1R41DK119052-01 and NIA P30-AG024832 [PI: E