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This unexpectedly promotes fibroblast activation and proliferation, thereby accelerating the fibrotic process ( 6.3.5 Targeting extracellular matrix remodeling Targeted inducers of matrix metalloproteinases (MMPs) exert complex effects on macrophage function in thyroid eye disease by regulating extracellular matrix remodeling: on the one hand, they may break the physical confinement of macrophages by moderately degrading excessively deposited fibrotic matrix, thereby promoting a shift from a pro-fibrotic phenotype towards an anti-inflammatory reparative state

Metal coordination bonds are advantageous due to their higher strength compared to other non-covalent bonds such as hydrogen bonds and - stacking and exhibit an overlapping effect with multiple coordination bonds (Luo et al., 2022)

And getting the data, making some just adjustments

10.1016/j.ccell.2017.01.006 32 GazdarA