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Excess adipose tissue produces inflammatory cytokines, which promote insulin resistance, which promotes further fat storage, which produces more cytokines

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Biochim Biophys Acta Mol Cell Biol Lipids (2020) 1865:158662

For example, when the promoter of miR-137 is highly methylated, the cells ability to uptake glutamine is enhanced, thereby reducing its inhibitory effect on the glutamine transporter ASCT2 [93]