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Prospective clinical studies indicate that patients with CP/CPPS exhibit significant impairment in multiple semen quality parameters compared to healthy males, manifesting as declines in total/progressive motility, normal morphology rates, and sperm viability, accompanied by an elevated sperm DNA fragmentation index (DFI) ( Beyond direct damage to the local microenvironment, CP/CPPS exerts remote negative regulatory effects via systemic pathways

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