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Description

Lipophilic constituents (notably eugenol) partition into and disorder the phospholipid bilayer, causing rapid loss of membrane potential, K + /ATP efflux and collapse of the proton-motile force (PMF)

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It suppresses ECM degradation, counteracts RSL3 mediated inhibition of GPX4, increases intracellular GSH levels and the GSH/GSSG ratio, reduces MDA content, and inhibits activation of the MAPK/NF-KB pathways, thereby protecting chondrocytes from ferroptosis (156)

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