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As previous studies demonstrated that a daily dose of 20 mg kg 1 of MDMG-935P for only 5 days effectively reduced oxalate in primary hyperoxaluric mice 54 , we chose to administer up to 10 mg kg 1 d 1 to account for the long duration of the treatments

Suppressing ROS at later stages promotes tissue repair and recovery

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4,5,8 The structural similarity between p53 DBD and that of its homologues p63 and p73 suggests that p28 could also bind to either p63 or p73 and potentially enhance the reported tumor suppressive activity of individual isomers 4,7,9 through a similar mechanism of post-translational stabilization that alters their ubiquitination