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There are likely many undiagnosed Wilson disease patients 1 in 10,000 to 30,000 individuals have Wilson disease and 1 in 90 individuals are carriers

Amplified inflammatory activity within astrocytes and microglia is a defining feature of neuroinflammation, marked by glial cell activation or infiltration of immune cells that subsequently drive the upregulation of pro-inflammatory mediators (Mendiola & Cardona 2018)