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An animal study showed that NAC increased histamine release in conjunction with fluoride.[ref] In people given IV n-acetylcysteine in a hospital setting for acetaminophen poisoning, about 8% of the patients had an anaphylactoid reaction, defined as cutaneous (urticaria, pruritus, angioedema) or systemic (hypotension, respiratory symptoms) within five hours of receiving the IV

Emelianova, A.A., Kuzmin, D.V., Panteleev, P.V., Sorokin, M., Buzdin, A.A., and Ovchinnikova, T.V., Front

Sun, Y.-K

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