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Although pre-clinical findings are encouraging, further research is necessary to fully understand their therapeutic efficacy and improve their bioavailability for clinical applications

Despite the primary injury due to mechanical force, diffuse and multifocal damage often appears, leading to diffuse axonal injury by blunt force of shearing, tearing, and stretching of the axon and further damage of the long-distance white matter connection, with large-scale network disconnection as the core mechanism of cognitive impairment

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