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CCM measures parameters including corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD) and corneal nerve fiber length (CNFL), all of which are significantly reduced in patients with subclinical and clinical DPN compared with controls

These traditional techniques are labor-intensive with restricted dynamic range for detecting low-abundance proteins and provide suboptimal resolution for proteins with extreme molecular weights or high hydrophobicity, including CFTR (Charro et al., 2011)

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1998) demonstrated dose-dependent GH release (ED50 ~80 nmol/kg), no cortisol or prolactin elevation, and a 24% increase in bone growth rate (52 vs 42 m/day) in rat models