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Description

P300-mediated histone lactylation has been observed to be predominantly localized at transcription start sites, significantly driving the malignancy of the U87MG GBM cell line and promoting immunosuppression in the GBM microenvironment

SOURCE: CDC Vital Signs, March 2017

The sequencing library for each sample was prepared using the same method described above for the plasmid DNA pools, with custom indices for the second-round PCR detailed in Supplementary Table 3