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Fitzgerald R, Bertucci V, Sykes JM, Duplechain JK

In its Complete Response Letter, FDA said results from the Phase III ROMAN trial, in combination with the GT-201 trial, were not sufficiently persuasive to establish substantial evidence of avasopasems effectiveness and safety in reducing these mouth sores

A parallel phenotype was observed in paraquat-treated fly model where Sp administration resulted in lower accumulation of oxygen radicals in mitochondria of brain neurons (Fig