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Several published studies indicate that patients with reduced TPMT or NUDT15 activity receiving usual doses of 6-MP or azathioprine, accumulate excessive cellular concentrations of active 6-TGNs, and are at higher risk for severe myelosupression

The photos were taken by Giorgio Calcagni , the photographer of Pirellis Direzione Propaganda, but also by the Publifoto agency and by well-known photographers such as Aldo Ballo and Giancarlo Scalfati

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The structures of the F-BAR domains in both crystals were almost identical, with a root mean square deviation of 1.2