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A fifth Aspect of the invention includes the first through the fourth Aspects of the invention, wherein the at least one builder is at least one compound selected from the group consisting of: tripolyphosphates, nitriloacetic acid salts, zeolites, calcite/carbonate, citrate or polymers, sodium, pyrophosphate, orthophosphate, sodium aluminosilicate, inorganic salts of alkaline agents, inorganic salts of alkali metals, sulphates, silicates, and metasilicates A sixth Aspect of the invention includes the first through the fifth Aspects of the invention further comprising: at least one bleach

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Blocking TDP-43 SUMOylation in vivo leads to female-specific social and cognitive deficits Following on our findings that blocking TDP-43 SUMOylation affect neurons abilities to recover from repeated or mild cellular stress, we posited that blocking TDP-43 SUMOylation in aging may render long lived cells (i.e