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This mechanism is a key reason why semaglutide's fat loss outcomes are so significant in clinical trials

In in vitro cell experiments, it is widely used to verify the relationship between NNMT activity and cellular energy metabolism

Much of the supporting research summarized in peer-reviewed literature relies on animal studies, such as GLP-1 receptor-knockout mice and rodent injection trials, rather than large-scale human trials, and peptide-based drugs overall are described as rarely used in real-world patient care because of lingering questions about safety, effectiveness, and inadequate insurance coverage

Early studies suggest it may be, but long-term research is still ongoing