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75 The renal toxicity of melamine is thus mediated by the GI microbiota and may depend on the exact composition and metabolic activities of the GI microbiota

YangCFuXHaoWXiangXLiuTYangBZet al

The first step is catalyzed by glutamate-cysteine ligase (GCL), which is composed of catalytic and modifier subunits (GCLC and GCLM)

This imbalance in lipid metabolism creates a lipotoxic microenvironment, where reactive oxygen species (ROS) are excessively produced due to the oxidation of FFAs, a key factor in driving cellular stress